Biological characterization of gastric surface mucous cell line GSM06 from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.

@article{Tabuchi1996BiologicalCO,
  title={Biological characterization of gastric surface mucous cell line GSM06 from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.},
  author={Yohiki Tabuchi and Norifumi Sugiyama and Tadashi Horiuchi and Kazuhisa Furuhama and Motonosuke Furusawa},
  journal={Digestion},
  year={1996},
  volume={57 2},
  pages={141-8}
}
We investigated the biological features of gastric surface mucous cell line GSM06, established from transgenic mice harboring the temperature-sensitive simian virus 40 large T-antigen gene. GSM06 cells grew until confluent monolayers were formed at the permissive temperature (33 degrees C), showing that the cessation of cell growth may be due to contact inhibition. Moreover, the cells did not grow in a soft agar gel. However, chromosome numbers of the cells were not normal. When GSM06 cells… CONTINUE READING