Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-part II.

@article{Sierra2007BiologicalCO,
  title={Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-part II.},
  author={Johanna Carolina Sierra and Giovanni Dell ’ Ariccia Luc Laeven Gustavo Suarez and Jian Sha and Sheri M. Foltz and Vsevolod L. Popov and Cristi L. Galindo and Harold R. Garner and Ashok Kumar Chopra},
  journal={Microbial pathogenesis},
  year={2007},
  volume={43 4},
  pages={147-60}
}
We recently identified a novel type III secretion system (T3SS) effector, AexU, from a diarrheal isolate SSU of Aeromonas hydrophila, and demonstrated that mice infected with the DeltaaexU mutant were significantly protected from mortality. Although the NH(2)-terminal domain of this toxin exhibits homology to AexT of A. salmonicida, a fish pathogen, and ExoT/S of Pseudomonas aeruginosa, the COOH-terminal domain of AexU is unique, with no homology to any known proteins in the NCBI database. In… CONTINUE READING