Biological basis of radiation sensitivity. Part 1: Factors governing radiation tolerance.

@article{Rosen2000BiologicalBO,
  title={Biological basis of radiation sensitivity. Part 1: Factors governing radiation tolerance.},
  author={Eliot M. Rosen and Saijun Fan and Itzhak D. Goldberg and Sara Rockwell},
  journal={Oncology},
  year={2000},
  volume={14 4},
  pages={543-50}
}
Local tumor recurrence after radiation therapy is due primarily to the failure to eradicate all of the tumor cells within the treatment fields. Theoretically, all cancers could be controlled locally if a sufficiently high radiation dose could be delivered to a treatment volume that encompassed all of the tumor cells. In practice, however, the administration of a radiation dose high enough to sterilize all of the tumor cells would pose an unacceptably high risk of severe damage to normal tissues… CONTINUE READING