Biological assay for activity and molecular mechanism of retinoids in cervical tumor cells.

  title={Biological assay for activity and molecular mechanism of retinoids in cervical tumor cells.},
  author={Doris Mangiaracina Benbrook and S. Lu and Courtney E Flanagan and Jane Shen-Gunther and Lee H. Angros and Stan A. Lightfoot},
  journal={Gynecologic oncology},
  volume={66 1},
The composition and response of the retinoid signaling pathway in a human cell line (CC-1), representative of a low grade cervical carcinoma, were evaluated. Reverse-transcriptase polymerase chain reaction (RT-PCR) analysis demonstrated expression of cytoplasmic retinol binding protein, CRBPI, cytoplasmic retinoic acid binding protein, CRABPII, and nuclear retinoic acid receptors, RAR alpha, RARgamma, RXR alpha, and RXRbeta, but not CRABPI or RARbeta. This pattern is similar to that of the… 

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