Biological and toxicological consequences of quinone methide formation.

  title={Biological and toxicological consequences of quinone methide formation.},
  author={David C. Thompson and John A. Thompson and Manickam Sugumaran and Peter Mold{\'e}us},
  journal={Chemico-biological interactions},
  volume={86 2},
Quinone methides are a class of reactive, electrophilic compounds which are capable of alkylating cellular macromolecules. They are formed during xenobiotic biotransformation reactions and are hypothesized to mediate the toxicity of a large number of quinone antitumor drugs as well as several alkylphenols. In addition, oxidation of specific endogenous alkylphenols (e.g. coniferyl alcohol) and alkylcatechols (e.g. N-acetyldopamine, dopa) to quinone methides plays an important role in the… CONTINUE READING