Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma.

@article{Mahlokozera2018BiologicalAT,
  title={Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma.},
  author={Tatenda Mahlokozera and Ananth K Vellimana and Tiandao Li and Diane D. Mao and Zohny S Zohny and David H. Kim and David Dinh Tran and Daniel S. Marcus and Sarah Jost Fouke and Jian Li Campian and Gavin P Dunn and Christopher A Miller and Albert H. Kim},
  journal={Neuro-oncology},
  year={2018},
  volume={20 4},
  pages={472-483}
}
Background Diagnostic workflows for glioblastoma (GBM) patients increasingly include DNA sequencing-based analysis of a single tumor site following biopsy or resection. We hypothesized that sequencing of multiple sectors within a given tumor would provide a more comprehensive representation of the molecular landscape and potentially inform therapeutic strategies. Methods Ten newly diagnosed, isocitrate dehydrogenase 1 (IDH1) wildtype GBM tumor samples were obtained from 2 (n = 9) or 4 (n = 1… CONTINUE READING
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