Biological and statistical approaches to predicting human lung cancer risk from silica.

@article{Kuempel2001BiologicalAS,
  title={Biological and statistical approaches to predicting human lung cancer risk from silica.},
  author={Eileen D. Kuempel and Carol T. Tran and A. John Bailer and David W. Porter and Ann F. Hubbs and Vincent Castranova},
  journal={Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
  year={2001},
  volume={20 Suppl 1},
  pages={
          15-32
        }
}
Chronic inflammation is a key step in the pathogenesis of particle-elicited fibrosis and lung cancer in rats, and possibly in humans. In this study, we compute the excess risk estimates for lung cancer in humans with occupational exposure to crystalline silica, using both rat and human data, and using both a threshold approach and linear models. From a toxicokinetic/dynamic model fit to lung burden and pulmonary response data from a subchronic inhalation study in rats, we estimated the minimum… CONTINUE READING
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