Biological and molecular characterization of a canine hemangiosarcoma-derived cell line.

@article{Thamm2006BiologicalAM,
  title={Biological and molecular characterization of a canine hemangiosarcoma-derived cell line.},
  author={Douglas H. Thamm and E B Dickerson and Nasim Mohammad Akhtar and Rachel Lewis and Robert D. Auerbach and Stuart C. Helfand and E. Gregory Macewen},
  journal={Research in veterinary science},
  year={2006},
  volume={81 1},
  pages={76-86}
}
Canine hemangiosarcoma (HSA) is a devastating disease. Investigation of novel therapies has been limited by the limited availability of canine HSA-derived cell lines. We report the development of a canine HSA-derived cell line, DEN-HSA, which recapitulates features of angiogenic endothelium. DEN-HSA cells were derived from a spontaneous HSA arising in the kidney of a dog. DEN-HSA displayed surface molecules distinctive of endothelial histogenesis, including factor VIII-related antigen, ICAM-1… CONTINUE READING