Biological and clinical significance of her2 overexpression in Breast Cancer

@article{Kurebayashi2001BiologicalAC,
  title={Biological and clinical significance of her2 overexpression in Breast Cancer},
  author={Junichi Kurebayashi},
  journal={Breast Cancer},
  year={2001},
  volume={8},
  pages={45-51}
}
The product of the HER2/neu proto-oncogene, HER2, is the second member of the human epidermal growth factor receptor (HER) family of tyrosine kinase receptors and has been suggested to be a ligand orphan receptor. Ligand-dependent heterodimerization between HER2 and another HER family member, HER1, HER3 or HERA, activates the HER2 signaling pathway. The intracellular signaling pathway of HER2 is thought to involve ras-MAPK, MAPK-independent S6 kinase and phospholipase C-γ signaling pathways… CONTINUE READING

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