Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia.

@article{Fabris2011BiologicalAC,
  title={Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia.},
  author={Sonia Fabris and Valentina Bollati and Luca Agnelli and Fortunato Morabito and Valeria Motta and Giovanna Cutrona and Serena Matis and Anna Grazia Recchia and Vincenzo Gigliotti and Massimo Gentile and Giorgio Lambertenghi Deliliers and Pier Alberto Bertazzi and Manlio Ferrarini and Antonino Neri and Andrea A. Baccarelli},
  journal={Epigenetics},
  year={2011},
  volume={6 2},
  pages={188-94}
}
Global DNA hypomethylation affecting repeat sequences has been reported in different cancer types. Herein, we investigated the methylation levels of repetitive DNA elements in chronic lymphocytic leukemia (CLL), their correlation with the major cytogenetic and molecular features, and clinical relevance in predicting therapy-free survival (TFS). A quantitative bisulfite-PCR Pyrosequencing method was used to evaluate methylation of Alu, long interspersed nuclear elements-1 (LINE-1) and satellite… CONTINUE READING