Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma

@article{Jung2010BiologicalAC,
  title={Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma},
  author={Alain Jung and Jenny Briolat and R{\'e}gine Millon and Aur{\'e}lien de Reyni{\`e}s and David S Rickman and Emilie Thomas and Joseph Abecassis and Christine Clavel and Bohdan Wasylyk},
  journal={International Journal of Cancer},
  year={2010},
  volume={126}
}
Human papillomaviruses (HPV) are associated with a subset of head and neck squamous cell carcinoma (HNSCC), particularly HPV16. This study analyzed the presence and genotype of high risk HPVs, viral DNA load and transcription of the E6/E7 mRNAs, in 231 consecutive HNSCC. Twelve out of 30 HPV16 DNA‐positive tumors displayed high E6/E7 mRNAs levels and were localized in the oropharyngeal region. While HPV‐free and non‐transcriptionally active HPV‐related patients showed similar 5‐years survival… 

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