Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: description of eight cases.

@article{CantRajnoldi1989BiologicalAC,
  title={Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: description of eight cases.},
  author={A Cant{\'u}-Rajnoldi and Rosangela Invernizzi and Andrea Biondi and Paolo Banfi and A Zoia and P Esposito De Fazio and N. Polli},
  journal={British journal of haematology},
  year={1989},
  volume={73 3},
  pages={309-14}
}
We describe eight patients (four children and four adults) with an acute lymphoblastic leukaemia (ALL) with cytoplasmic granules or inclusions. The incidence of this variant of acute leukaemia in our whole series of patients with ALL is 1.8%. The granules or inclusions were usually positive for aspecific esterases (ANAE) and/or acid phosphatase, and the immunophenotype was in all cases typical of a CALLA positive B-lineage ALL (CD10+, CD19+ and/or CD24+, DR+, TdT+, anti-T-, anti-My-, SIg-). In… CONTINUE READING