Biological and clinical associations of c-jun activation in human breast cancer.

@article{Gee2000BiologicalAC,
  title={Biological and clinical associations of c-jun activation in human breast cancer.},
  author={Julia M. W. Gee and Ana Val{\'e}ria Farias Barroso and Ian O. Ellis and John F. R. Robertson and Robert Ian Nicholson},
  journal={International journal of cancer},
  year={2000},
  volume={89 2},
  pages={177-86}
}
Sub-units and regulators of the activating protein-1(AP-1) complex have been implicated in breast-cancer biology, therapeutic response and prognosis. This study has immunocytochemically examined the impact of c-jun-protein activation on biological and clinical parameters in human primary breast cancers, employing an antibody specific for the serine 63-phosphorylated c-jun protein. Substantial nuclear immunostaining was commonly apparent, indicative of an activated c-jun pool, with associations… CONTINUE READING
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