Biological and biomedical implications of the co-evolution of pathogens and their hosts

@article{Woolhouse2002BiologicalAB,
  title={Biological and biomedical implications of the co-evolution of pathogens and their hosts},
  author={Mark E. J. Woolhouse and Joanne P. Webster and Esteban Domingo and Brian Charlesworth and Bruce R. Levin},
  journal={Nature Genetics},
  year={2002},
  volume={32},
  pages={569-577}
}
Co-evolution between host and pathogen is, in principle, a powerful determinant of the biology and genetics of infection and disease. Yet co-evolution has proven difficult to demonstrate rigorously in practice, and co-evolutionary thinking is only just beginning to inform medical or veterinary research in any meaningful way, even though it can have a major influence on how genetic variation in biomedically important traits is interpreted. Improving our understanding of the biomedical… 

Evolutionary insights into host–pathogen interactions from mammalian sequence data

TLDR
The latest developments in comparative immunology and evolutionary genetics are described, showing their relevance for understanding the molecular determinants of infection susceptibility in mammals.

Host-parasite co-evolution and its genomic signature.

TLDR
This work has indicated that host-parasite co-evolution is responsible for the extraordinary genetic diversity seen in some genomic regions, such as major histocompatibility genes in jawed vertebrates and resistance genes in plants, but the mechanisms that link the genomic signatures in these regions to the underlying co-Evolutionary process are only slowly emerging.

Disrupted human–pathogen co-evolution: a model for disease

TLDR
It is suggested that disrupted co-evolution between a pathogen and its human host can explain variation in disease outcomes, and that genome-by-genome interactions should therefore be incorporated into genetic models of disease caused by infectious agents.

An ecological and evolutionary perspective on human–microbe mutualism and disease

TLDR
The shared evolutionary fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease.

Pathogenetic consequences of cytomegalovirus-host co-evolution

TLDR
This review explores the pathogenetic consequences emerging from the behavioral changes caused by co-evolutionary forces on the virus and its host.

FITNESS OF INDIRECTLY TRANSMITTED PATHOGENS: RESTRAINT AND CONSTRAINT

Abstract Many pathogens of medical and veterinary importance have obligatory multihost life cycles. Yet, theoretical models aiming to predict patterns of pathogen reproductive success and the limited

Plant Pathogen Co-evolution in Rice Crop

TLDR
The framework of co-evolution theory is discussed, which describes how a wide range of many other micro- and macroevolutionary processes occur concurrently in a single plant, posing the issue of whether or not to even discuss it.
...

References

SHOWING 1-10 OF 133 REFERENCES

A MATHEMATICAL MODEL FOR THE CO‐EVOLUTION OF OBLIGATE PARASITES AND THEIR HOSTS

TLDR
The genetic systems uncovered by the work of Flor, Briggs, and his associates will be briefly reviewed and their evolutionary significance will be interpreted from the standpoint of population genetics.

Population Biology of Multihost Pathogens

TLDR
The majority of pathogens, including many of medical and veterinary importance, can infect more than one species of host, and factors that predispose pathogens to generalism include high levels of genetic diversity and abundant opportunities for cross-species transmission.

Genetics of host-parasite interactions.

Genes Lost and Genes Found: Evolution of Bacterial Pathogenesis and Symbiosis

TLDR
This work has shown that changes in genome repertoire, occurring through gene acquisition and deletion, are the major events underlying the emergence and evolution of bacterial pathogens and symbionts.

The evolution and maintenance of virulence in microparasites.

  • B. Levin
  • Biology
    Emerging infectious diseases
  • 1996
TLDR
These hypotheses for the evolution and maintenance of microparasite virulence are critically reviewed, and suggestions are made for testing them experimentally.

Experimental evolution of parasites.

TLDR
Serial passage experiments show that within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts.

Gene-for-gene coevolution between plants and parasites

TLDR
The emerging pattern from these studies suggests that metapopulation structure may be at least as important as local natural selection in determining the genetic dynamics and outcomes of these evolutionary arms races.

Infection genetics: gene-for-gene versus matching-alleles models and all points in between

TLDR
The controversy between plant pathologists and invertebrate zoologists as to the genetic basis of infection is addressed, and it is shown that the alternative models proposed by these groups represent two ends of a continuum.

The Ecology of Genetically Diverse Infections

TLDR
Microparasite infections often consist of genetically distinct clonal lineages that influence disease severity, epidemiology, and evolution, and much of the theory in this area is based on assumptions contradicted by the available data.

Population biology of emerging and re-emerging pathogens.

...