Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. I. Objectives, subject selection, laboratory procedures, and estimation of analytic deviation.

@article{Williams1970BiologicalAA,
  title={Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. I. Objectives, subject selection, laboratory procedures, and estimation of analytic deviation.},
  author={Gretchen Williams and Douglas S. Young and Mark R. Stein and E Cotlove},
  journal={Clinical chemistry},
  year={1970},
  volume={16 12},
  pages={
          1016-21
        }
}
A study of blood constituents in normal individuals was undertaken to (a) estimate the contribution of biological and analytical factors to the variation of constituents over an extended time period; (b) to explore whether such tests can be used to derive meaningful personal blood “profiles”; and (c) to determine when analytic variation may become large enough to assume medical significance. This first paper describes procedures for subject selection, the laboratory methods employed, and… CONTINUE READING
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