Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

@inproceedings{Yamada2010BiologicalAS,
  title={Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus},
  author={Shinya Yamada and Masato Hatta and Bart L. Staker and Shinji Watanabe and Masaki Imai and Kyoko Shinya and Yuko Sakai-Tagawa and Mutsumi Bunkyo-ku Ito and Makoto Ozawa and Tokiko Watanabe and Saori Sakabe and Chengjun Li and Jin Hyun Kim and Peter J. Myler and Isabelle Phan and Amy Raymond and Eric Wiebe Bethany Smith and Robin L. Stacy and Chairul A. Nidom and Simon M. Lank and Roger Wiseman and Benjamin N. Bimber and David H. O'Connor and Gabriele Neumann and Lance J. Stewart and Yoshihiro Kawaoka},
  booktitle={PLoS pathogens},
  year={2010}
}
Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of avian influenza A viruses to mammals. However, the recently emerged pandemic H1N1 viruses lack these amino acids. Here, we report that a basic amino acid at position 591 of PB2 can compensate for the lack of lysine at position 627 and confers efficient viral replication to pandemic H1N1 viruses in mammals. Moreover, a basic amino acid at… CONTINUE READING

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