Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches

@inproceedings{Morimoto2017BiologicalAP,
  title={Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches},
  author={Daichi Morimoto and Erik Walinda and Kenji Sugase and Masahiro Shirakawa},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Most intracellular proteins are subjected to post-translational modification by ubiquitin. Accordingly, it is of fundamental importance to investigate the biological and physicochemical effects of ubiquitylation on substrate proteins. However, preparation of ubiquitylated proteins by an enzymatic synthesis bears limitations in terms of yield and site-specificity. Recently established chemical ubiquitylation methodologies can overcome these problems and provide a new understanding of… CONTINUE READING

Citations

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Ubiquitin System

  • International journal of molecular sciences
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Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation

  • International journal of molecular sciences
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