Biological activity of some oxygenated sterols.

@article{Kandutsch1978BiologicalAO,
  title={Biological activity of some oxygenated sterols.},
  author={Andrew A. Kandutsch and Harry W. Chen and H. J. Heiniger},
  journal={Science},
  year={1978},
  volume={201 4355},
  pages={498-501}
}
A group of oxygenated sterols has been identified as potent and specific inhibitors of sterol biosynthesis. The ability of these compounds to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated sterol rather than by cholesterol. The nature of the regulatory sterol may vary in different cells with their specific requirements for cholesterol as a… CONTINUE READING

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