Biological activity of des-Asp1-angiotensin I in man.

  title={Biological activity of des-Asp1-angiotensin I in man.},
  author={T. K{\^o}no and F. Ikeda and F. Oseko and H. Imura and J. Endo},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={50 1},
  • T. Kôno, F. Ikeda, +2 authors J. Endo
  • Published 1980
  • Chemistry, Medicine
  • The Journal of clinical endocrinology and metabolism
  • The biological activity of des-Asp1-angiotensin I (des-Asp1-AI) was studied in five normal men. An iv infusion of 300 ng (258 pmol)/kg.min des-Asp1-AI caused a remarkable rise in blood pressure, a decrease in PRA, and an increase in plasma aldosterone concentration. The pressor and steroidogenic actions of this dose of des-Asp1-AI were slightly less than those of 100 ng (111 pmol)/kg.min des-Asp1-angiotensin II [Angotensin III (AIII)] which we reported previously and were abolished by a single… CONTINUE READING
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