Biological activity of carboxy-terminal gastrin analogs.

@article{Sandvik1999BiologicalAO,
  title={Biological activity of carboxy-terminal gastrin analogs.},
  author={Arne K. Sandvik and Graham J. Dockray},
  journal={European journal of pharmacology},
  year={1999},
  volume={364 2-3},
  pages={199-203}
}
Amidated forms of gastrin are derived by post-translational processing of a large precursor peptide and stimulate gastric acid secretion via the gastrin/CCK(B) receptor. Non-amidated biosynthetic intermediates may exert biological effects through other mechanisms, but their effect on gastric acid secretion is unclear. Amidated gastrins stimulate acid secretion mainly by releasing histamine from mucosal enterochromaffin-like cells. This study examines the effects on histamine release from the… CONTINUE READING