Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines.

@article{Chimento2013BiologicalAO,
  title={Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines.},
  author={Adele Chimento and Marina Sala and Isabel M Gomez-Monterrey and Simona Musella and Alessia Bertamino and Anna Caruso and Maria Stefania Sinicropi and Rosa Sirianni and Francesco Puoci and Ortensia Ilaria Parisi and Carmela Campana and Emilia Martire and Ettore Novellino and C. Saturnino and Pietro Campiglia and Vincenzo Pezzi},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 23},
  pages={6401-5}
}
Resveratrol (3,4',5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic agent capable of inducing tumor cell death in a variety of cancer types. However, therapeutic application of these beneficial effects remains very limited due to its short biological half-life, labile properties, rapid metabolism and elimination. Different studies were undertaken to obtain synthetic analogs of resveratrol with major bioavailability and anticancer activity. We have… CONTINUE READING

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