Biological activity and binding of estradiol to SK-Mel 23 human melanoma cells.

@article{Sarti2004BiologicalAA,
  title={Biological activity and binding of estradiol to SK-Mel 23 human melanoma cells.},
  author={Maddalena Sarti and Maria Aparecida Visconti and Ana Maria de Lauro Castrucci},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2004},
  volume={37 6},
  pages={
          901-5
        }
}
Patients expressing estradiol receptors in melanoma cells have been reported to have a better prognosis. We therefore decided to investigate the in vitro effects of beta-estradiol and tamoxifen on the growth and tyrosinase activity of SK-Mel 23 human melanoma cells. Twenty-four-hour treatment with 0.4 nM beta-estradiol inhibited cell proliferation in 30% (0.70 +/- 0.03 x 10(5) cells) and increased tyrosinase activity in 50% (7130.5 +/- 376.5 cpm/10(5) cells), as compared to untreated cells (1.0… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and ß

Kuiper GGJM, B Carlsson, +4 authors J Gustafsson
  • Endocrinology
  • 1997

Phospholipase Cß and membrane action of calcitriol and estradiol

V Le Mellay, B Grosse, M Lieberherr
  • Journal of Biological Chemistry,
  • 1997
VIEW 1 EXCERPT