Biological activities on T lymphocytes of a baculovirus-expressed chimeric recombinant IgG1 antibody with specificity for the CDR3-like loop on the D1 domain of the CD4 molecule.

Abstract

A baculovirus-expressed chimeric recombinant IgG1 (rIgG1) antibody, with Cgamma1 and Ckappa human constant domains, was derived from the murine monoclonal antibody (mAb) 13B8.2, which is specific for the CDR3-like loop of the CD4 molecule and which inhibits HIV-1 replication. Chimeric rIgG1 antibody 13B8.2 blocked, in a dose-dependent manner, antigen… (More)

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@article{Troadec2006BiologicalAO, title={Biological activities on T lymphocytes of a baculovirus-expressed chimeric recombinant IgG1 antibody with specificity for the CDR3-like loop on the D1 domain of the CD4 molecule.}, author={Samuel Troadec and C. Bes and Myriam Chentouf and Brigitte Nguyen and Laurence Briant and Chantal Jacquet and Karim Ch{\'e}bli and Martine Pugni{\`e}re and Françoise Roquet and Martine C{\'e}rutti and Thierry Chard{\`e}s}, journal={Clinical immunology}, year={2006}, volume={119 1}, pages={38-50} }