Biological Response Modifiers and Normal Tissue Injury After Irradiation.

  title={Biological Response Modifiers and Normal Tissue Injury After Irradiation.},
  journal={Seminars in radiation oncology},
  volume={4 2},
  • Hendry
  • Published 1994 in Seminars in radiation oncology
The reactions of tissues after irradiation can be modified using a variety of biologically based approaches. Cellular radiosensitivity can be changed using growth regulatory molecules (GRM) that have cell-cycle-mediated effects. Radiosensitivity can also be changed using prostaglandins, dose-miodifying factors of up to around 2 can be achieved. Proliferation and differentiation of precursor cells in early-reacting tissues can be promoted by GRM, producing substantial dose-modifying factors in… CONTINUE READING


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