Biological Production of Semisynthetic Opiates Using Genetically Engineered Bacteria

@article{French1995BiologicalPO,
  title={Biological Production of Semisynthetic Opiates Using Genetically Engineered Bacteria},
  author={Christopher E. French and Anne M. Hailes and Deborah A. Rathbone and Marianne T. Long and David Willey and Neil C Bruce},
  journal={Bio/Technology},
  year={1995},
  volume={13},
  pages={674-676}
}
Semisynthetic derivatives of morphine and related alkaloids are in widespread clinical use. Due to the complexity of these molecules, however, chemical transformations are difficult to achieve in high yields. We recently identified the powerful analgesic hydromorphone as an intermediate in the metabolism of morphine by Pseudomonas putida M10. Here we describe the construction of recombinant strains of Escherichia coli that express morphine dehydrogenase and morphinone reductase. These strains… CONTINUE READING
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