Biological Insights From 108 Schizophrenia-Associated Genetic Loci

@article{Ripke2014BiologicalIF,
  title={Biological Insights From 108 Schizophrenia-Associated Genetic Loci},
  author={S. Ripke and B. Neale and A. Corvin and J. Walters and K. Farh and P. Holmans and P. Lee and B. Bulik-Sullivan and D. Collier and Hailiang Huang and T. H. Pers and I. Agartz and E. Agerbo and M. Albus and M. Alexander and F. Amin and S. Bacanu and M. Begemann and R. Belliveau and J. Bene and Sarah L Bergen and Elizabeth Bevilacqua and T. Bigdeli and D. Black and R. Bruggeman and N. Buccola and R. Buckner and W. Byerley and W. Cahn and Guiqing Cai and D. Campion and R. Cantor and V. Carr and N. Carrera and S. Catts and K. Chambert and R. Chan and Ronald Y. L. Chan and E. Y. Chen and Wei Cheng and E. Cheung and S. Chong and C. R. Cloninger and D. Cohen and N. Cohen and P. Cormican and N. Craddock and J. Crowley and D. Curtis and M. Davidson and K. Davis and F. Degenhardt and J. Del Favero and D. Demontis and D. Dikeos and T. Dinan and S. Djurovic and G. Donohoe and E. Drapeau and J. Duan and F. Dudbridge and N. Durmishi and P. Eichhammer and J. Eriksson and V. Escott-Price and L. Essioux and A. Fanous and M. Farrell and J. Frank and L. Franke and R. Freedman and N. Freimer and M. Friedl and J. Friedman and M. Fromer and G. Genovese and L. Georgieva and I. Giegling and P. Giusti-Rodr{\'i}guez and S. Godard and J. Goldstein and V. Golimbet and S. Gopal and J. Gratten and L. de Haan and C. Hammer and M. Hamshere and M. Hansen and T. Hansen and V. Haroutunian and A. Hartmann and F. Henskens and S. Herms and J. Hirschhorn and P. Hoffmann and A. Hofman and M. Hollegaard and D. Hougaard and M. Ikeda and I. Joa and A. Juli{\`a} and R. Kahn and L. Kalaydjieva and S. Karachanak-Yankova and J. Karjalainen and D. Kavanagh and M. Keller and J. Kennedy and A. Khrunin and Y. Kim and J. Klovins and J. Knowles and B. Konte and V. Kučinskas and Z. A. Ku{\vc}inskienė and Hana Kuzelova-Ptackova and A. K{\"a}hler and C. Laurent and J. Lee and S. Lee and S. Legge and B. Lerer and Miaoxin Li and Tao Li and K. Liang and J. Lieberman and S. Limborska and C. Loughland and J. Lubiński and J. L{\"o}nnqvist and M. Macek and P. Magnusson and B. Maher and W. Maier and J. Mallet and S. Marsal and M. Mattheisen and M. Mattingsdal and R. McCarley and C. McDonald and A. McIntosh and S. Meier and C. Meijer and B. Melegh and I. Melle and R. Mesholam-Gately and A. Metspalu and P. Michie and L. Milani and V. Milanova and Y. Mokrab and D. Morris and O. Mors and K. Murphy and R. Murray and I. Myin-Germeys and B. M{\"u}ller-Myhsok and M. Nelis and I. Nenadi{\'c} and D. Nertney and G. Nestadt and K. Nicodemus and L. Nikitina-Zake and L. Nisenbaum and A. Nordin and E. O’Callaghan and C. O'Dushlaine and F. O’Neill and S. Oh and A. Olincy and L. Olsen and J. van os and C. Pantelis and G. Papadimitriou and S. Papiol and E. Parkhomenko and M. Pato and T. Paunio and M. Pejovic-Milovancevic and D. Perkins and O. Pietil{\"a}inen and J. Pimm and A. Pocklington and J. Powell and A. Price and A. Pulver and S. Purcell and D. Quested and H. Rasmussen and A. Reichenberg and M. Reimers and A. Richards and J. Roffman and P. Roussos and D. Ruderfer and V. Salomaa and A. Sanders and U. Schall and C. Schubert and T. Schulze and S. Schwab and E. Scolnick and R. Scott and L. Seidman and Jianxin Shi and E. Sigurdsson and T. Silagadze and J. Silverman and K. Sim and P. Slominsky and J. Smoller and H. So and C. Spencer and E. Stahl and H. Stef{\'a}nsson and S. Steinberg and E. Stogmann and R. Straub and E. Strengman and J. Strohmaier and T. Stroup and M. Subramaniam and J. Suvisaari and D. Svrakic and J. Szatkiewicz and E. S{\"o}derman and S. Thirumalai and D. Toncheva and S. Tosato and J. Veijola and J. Waddington and D. Walsh and Dai Wang and Q. Wang and B. Webb and M. Weiser and D. Wildenauer and N. Williams and Stephanie Williams and S. Witt and A. Wolen and Emily H. M. Wong and B. Wormley and H. Xi and C. Zai and X. Zheng and F. Zimprich and N. Wray and K. Stef{\'a}nsson and P. Visscher and R. Adolfsson and O. Andreassen and D. Blackwood and E. Bramon and J. Buxbaum and A. B{\o}rglum and S. Cichon and A. Darvasi and E. Domenici and H. Ehrenreich and T. Esko and P. Gejman and M. Gill and H. Gurling and C. Hultman and N. Iwata and A. Jablensky and E. J{\"o}nsson and K. Kendler and G. Kirov and J. Knight and T. Lencz and D. Levinson and Q. Li and J. Liu and A. Malhotra and S. McCarroll and A. McQuillin and J. Moran and P. Mortensen and B. Mowry and M. N{\"o}then and R. Ophoff and M. Owen and A. Palotie and C. Pato and T. Petryshen and D. Posthuma and M. Rietschel and B. Riley and D. Rujescu and P. Sham and P. Sklar and D. St Clair and D. Weinberger and J. Wendland and T. Werge and M. Daly and P. Sullivan and M. O’Donovan},
  journal={Nature},
  year={2014},
  volume={511},
  pages={421 - 427}
}
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations… Expand
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