Biological Effects and Biodistribution of Bufotenine on Mice

  title={Biological Effects and Biodistribution of Bufotenine on Mice},
  author={Hugo Vigerelli and Juliana Mozer Sciani and Maria Andrea Camarano Eula and Luciana Almeida Sato and Marta Marta Antoniazzi and Carlos Jared and Daniel Carvalho Pimenta},
  journal={BioMed Research International},
Bufotenine is an alkaloid derived from serotonin, structurally similar to LSD and psilocin. This molecule is able to inhibit the rabies virus infection in in vitro and in vivo models, increasing the survival rate of infected animals. Being a very promising molecule for an incurable disease and because of the fact that there is no consensus regarding its neurological effects, this study aimed to evaluate chronic treatment of bufotenine on behavior, pathophysiology, and pharmacokinetics of mice… 

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Psychoptic activity of bufotenine has been established and the 1967 Holmstedt–Lindgren hypothesis of the paricá effect—intranasal potentiation of tryptamines by concomitant administration of monoamine-oxidase-inhibiting (MAOI) β-carbolines from stems of Banisteriopsis caapi admixed with the snuffs—has been confirmed by 25 psychonautic bioassays.


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The field of inquiry is limited by a definition that will prevent workers in this field from being overwhelmed with an inconveniently large poition of the pharmacopoeia, and this rough and ready guide excludes morphine, cocaine, atropine, and their derivatives.