• Corpus ID: 16799999

Biological Characteristics Prognosis of Oral Premalignant Lesions : Significance of Clinical , Histopathological , and Molecular

  title={Biological Characteristics Prognosis of Oral Premalignant Lesions : Significance of Clinical , Histopathological , and Molecular},
  author={Jesper Reibel},
The concept of a two-step process of cancer development in the oral mucosa, i.e., the initial presence of a precursor subsequently developing into cancer, is well-established. Oral leukoplakia is the best-known precursor lesion. The evidence that oral leukoplakias are pre-malignant is mainly derived from follow-up studies showing that between < 1 and 18% of oral pre-malignant lesions will develop into oral cancer; it has been shown that certain clinical sub-types of leukoplakia are at a higher… 
1 Citations

Figures and Tables from this paper

A contemporary non-invasive method for assessing oral precancerous lesions
The loss of autofluorescence seems to be the most promising non-invasive method for identification of epithelial dysplasia in the oral cavity.


Lack of molecular markers to predict malignant potential of oral precancer
P53 protein stabilization, or indeed the spectrum of mutations of p53, has no major relationship to the biological characteristics and outcome of oral leukoplakia and when used as a single marker, p53 is unsuitable for the prediction of tumour development in high‐risk subjects and no other maker has yet emerged as useful.
The pathology of oral cancer and precancer
Oral leukoplakia: a clinicopathological review.
Potentially malignant oral lesions in northern Ireland: a 20-year population-based perspective of malignant transformation.
Data suggest that white lesions are only rarely the pre-invasive phase of OSCC, and it is possible therefore that early changes are red, small or even microscopic with carcinoma developing without a clinically observable phase.
p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma
The results suggest that clear expression of p53 above the basal cell layer is an early event in oral carcinogenesis and an indicator of a developing carcinoma, even preceding morphological tissue alterations.
Oral epithelial dysplasia and the development of invasive squamous cell carcinoma.
Loss of heterozygosity: a potential tool in management of oral premalignant lesions?
  • L. Zhang, M. Rosin
  • Medicine
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 2001
Oral leukoplakia, a heterogeneous group of lesions, demonstrates a varying degree of risk for cancer progression. Histology (presence and degree of dysplasia), the current gold standard for assessing
Development of squamous cell carcinoma from pre-existent oral leukoplakia: with respect to treatment modality.
The results suggest that surgical excision of oral leukoplakia may reduce the risk of the subsequent development of carcinoma.
DNA content as a prognostic marker in patients with oral leukoplakia.
The DNA content in cells of oral leukoplakia can be used to predict the risk of oral carcinoma.