Biological Activity of Cannabichromene, its Homologs and Isomers

  title={Biological Activity of Cannabichromene, its Homologs and Isomers},
  author={Carlton E. Turner and Mahmoud A. Elsohly},
  journal={The Journal of Clinical Pharmacology},
  • C. TurnerM. Elsohly
  • Published 9 August 1981
  • Biology, Chemistry
  • The Journal of Clinical Pharmacology
Abstract: Cannabichromene (CBC) is one of four major cannabinoids in Cannabis sativa L. and is the second most abundant cannabinoid in drug‐type cannabis. Cannabichromene and some of its homologs, analogs, and isomers were evaluated for antiinflammatory, antibacterial, and antifungal activity. Antiinflammatory activity was evaluated by the carrageenan‐induced rat paw edema and the erythrocyte membrane stabilization method. In both tests, CBC was superior to phenylbutazone. Antibacterial… 

Cannabinoids-Promising Antimicrobial Drugs or Intoxicants with Benefits?

  • P. Klahn
  • Biology, Medicine
  • 2020
It is time to discuss whether cannabinoids are promising antimicrobial drug candidates or overhyped intoxicants with benefits.

Cannabinoids: Biosynthesis and Biotechnological Applications

This chapter describes the history of the biosynthesis studies, in particular those focused on the biosynthetic enzymes, and recent topics linked to cannabinoid-related biotechnology.

Cannabinoids: occurrence and medicinal chemistry.

A survey of the more recent advances in both phytochemistry of C. sativa, the medicinal chemistry of cannabinoids, and their distribution in plants is given, highlighting the impact that research in these hot fields could have for modern medicinal chemistry and pharmacology.

Cannabigerol and cannabichromene in Cannabis sativa L.

Cannabinoid CBG exerts modest analgesic properties in rodents, as well as anti-fungal, anti-bacterial, pro-apoptotic, and anti-proliferative effects in tumor cells.

Marine Bioactive Compounds: Stereospecific Anti‐Inflammatory Activity of Natural and Synthetic Cordiachromene A

Comparison of results of the first test suggests that only the natural optically active isomer has an anti‐inflammatory effect, which is similar to indomethacin in its effect on carrageenan‐induced rat‐paw edema and ten times as active as phenylbutazone.

Inhibitory effect of cannabichromene, a major non‐psychotropic cannabinoid extracted from Cannabis sativa, on inflammation‐induced hypermotility in mice

The effect of CBC is investigated on mouse intestinal motility in physiological and pathological states and it is shown that both endocannabinoids and TRPA1 may modulate gastrointestinal motility.

Prospects for cannabinoids as anti‐inflammatory agents

  • R. Zurier
  • Biology
    Journal of cellular biochemistry
  • 2003
A portion of the work done by investigators interested in separating the medicinal properties of marijuana from its psychoactive effects is reviewed, finding several marijuana constituents, the carboxylic acid metabolites of tetrahydrocannabinol, and synthetic analogs are free of cannabimimetic central nervous system activity, do not produce behavioral changes in humans, and are effective antiinflammatory and analgesic agents.

The Antimicrobial Activity of Cannabinoids

This paper seeks to review the research to date on cannabinoids in this context, including an analysis of structure–activity relationships, and is hoped that it will stimulate further interest in this important issue.



Constituents of cannabis sativa L. An improved method for the synthesis of dl‐cannabichromene

A new procedure was developed for the synthesis of cannabichromene (III) which involves reflux of equimolar amounts of olivetol (I), citral (II) and t-butylamine in toluene for 9 hours. The

Constituents of Cannabis sativa L. IV. Stability of cannabinoids in stored plant material.

Tentative evidence supports the possible formation of hexahydrocannabinol as a decomposition product in stored C .

Constituents of cannabis sativa L. XVI. A possible decomposition pathway of Δ9‐tetrahydrocannabinol to cannabinol

A pathway is proposed for the decomposition of Δ9-tetrahydroeannabinol (I) and its Δ8-isomer (IX) with the eventual formation of cannabinol (II) through epoxy and hydroxylated intermediates.

Recent advances in the chemistry of hashish.

  • R. MechoulamY. Gaoni
  • Medicine
    Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles
  • 1967
Cannabis saliva L. (family Moraceae) is a dioecious plant of which two varieties exist, var. indica and var. non indica or typica. The flowering top of the female plant is covered with glandular

Synthesis of cannabinoids by pyridine-catalysed citral–olivetol condensation: synthesis and structure of cannabicyclol, cannabichromen, (hashish extractives), citrylidene-cannabis, and related compounds

Citral condenses with olivetol in the presence of pyridine (1 mol) to give citrylidene-cannabis(III)(26%), cannabi-chromen (IV)(15%), its isomer (V)(3%) the bischromen (II)(6%), cannabicyclol

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.

A Novel in vitro Assay for Anti-Inflammatory Agents Based on Stabilization of Erythrocytes

  • J. BrownH. MackeyD. A. Riggilo
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1967
Summary An in vitro technique for screening nonsteroidal anti-inflammatory compounds based on their ability to inhibit heat-induced hemolysis of canine erythrocytes has been demonstrated by

MARIHUANA: An Annotated Bibliography

Constituents of Cannabis sativa L. XVII. A review of the natural constituents.