Biological Activities of Sulfated Glycosides from Echinoderms

@article{Maier2008BiologicalAO,
  title={Biological Activities of Sulfated Glycosides from Echinoderms},
  author={Marta S. Maier},
  journal={Studies in natural products chemistry},
  year={2008},
  volume={35},
  pages={311-354}
}
  • M. Maier
  • Published 2008
  • Chemistry
  • Studies in natural products chemistry
Cytotoxic Triterpene Glycosides from Sea Cucumbers
TLDR
The structural characteristics and the cytotoxic properties of triterpene glycosides isolated from sea cucumbers in the last five years are reviewed, focusing on structure-activity correlations and research on their mechanisms of action.
Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades
TLDR
The structure of acetylated saponins, their biological activity, and their structure-activity relationships are highlighted; including induction of caspase, apoptosis, cytotoxicity, anticancer, antifungal and antibacterial activities of these compounds.
Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)
TLDR
The here presented data revealed that holothurians, holotoxins, cucumariosides, and echinosids are not only the most abundant saponin compounds in various genera of sea cucumbers but that these saponins can also be used as potential chemotaxonomic markers for different sea cucumber species.
Triterpenoids in Echinoderms: Fundamental Differences in Diversity and Biosynthetic Pathways
TLDR
This review aims to highlight the diversity of triterpenoids in echinoderms by focusing on sterols andtriterpenoid glycosides, but more importantly to provide an updated view of the biosynthesis of these molecules in echinoidea.
Impact of the Hydrolysis and Methanolysis of Bidesmosidic Chenopodium quinoa Saponins on Their Hemolytic Activity
Saponins are specific metabolites abundantly present in plants and several marine animals. Their high cytotoxicity is associated with their membranolytic properties, i.e., their propensity to disrupt
Biological and taxonomic perspective of triterpenoid glycosides of sea cucumbers of the family Holothuriidae (Echinodermata, Holothuroidea).
Molecular diversity and body distribution of saponins in the sea star Asterias rubens by mass spectrometry.
The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish
TLDR
The deterrent effect of saponins seems to act as an aposematic signal, warning potential predators of the unpalatability of the holothuroid tissues.
Mechanisms involved in pearlfish resistance to holothuroid toxins
TLDR
Results provide a new understanding of the carapids–holothuroids relationship and show that a great quantity of mucus can protect carapid fishes from their host’s saponins and acts as a mechanical barrier against toxins.
Antiproliferative, Cytotoxic and Hemolytic Activities of a Triterpene Glycoside from Psolus patagonicus and Its Desulfated Analog
TLDR
Although glycosides 1 and 2 exert an antiproliferative effect, their mechanisms of action do not involve inhibition of NF-κB and more extensive studies are needed to establish a mechanism of action and to deduce a clear structure-activity relationship of sea cucumber triterpene glycoside.
...
...

References

SHOWING 1-10 OF 80 REFERENCES
Biological activities of steroid glycosides from starfish.
Cytotoxic Triterpene Glycosides from Far‐Eastern Sea Cucumbers Belonging to the Genus Cucumaria
New cytotoxic triterpene oligoglycoside disulfates, cucumariosides A3 (1) and A6-2 (2), have been isolated from the sea cucumber Cucumaria japonica. The trisulfated cucumarioside A7-3 (4) was found
Triseramide is a New Steroid Conjugate from the Starfish Astropecten triseriatus
TLDR
The ethanol extract of the starfish Astropecten triseriatus collected in the Fiji Sea during the 15th expedition onboard the research ship Akademik Oparin was studied to continue research into steroid compounds of starfish.
Three new asterosaponins from the starfish Culcita novaeguineae and their bioactivity.
TLDR
Three new sulfated steroidal glycosides (asterosaponins) 1, 2 and 3 are isolated, as active compounds causing morphological abnormality of Pyricularia oryzae mycelia, by bioassay-guided fractionation of the active n-BuOH extract of the starfish Culcita novaeguineae.
Triterpene glycosides from the Far Eastern sea cucumber Cucumaria conicospermium.
Four new triterpene glycosides, cucumariosides A(2)-5 (1), A(3)-2 (2), A(3)-3 (3), and isokoreoside A (4), along with the previously isolated koreoside A (5), have been found in the sea cucumber
Starfish saponins. 55. Isolation, structure elucidation, and biological activity of the steroid oligoglycosides from an Antarctic starfish of the family Asteriidae.
TLDR
Eight of the compounds from an Antarctic starfish of the family Asteriidae were tested against human nonsmall-cell lung carcinoma cells and found to be moderately cytotoxic.
Free sterols from the holothurians Synapta maculata, Cladolabes bifurcatus and Cucumaria sp.
Saponins Used in Traditional and Modern Medicine
TLDR
Commercial Utilization and Biosynthesis: CommercialUtilization of Plantderived Saponins: An Overview of Medicinal, Pharmaceutical, and Industrial Applications M.F. Packowski, Z.A. Wojciechowski, and C.K. Paseshnichenko.
...
...