Biological Activities of Brucella abortus Lipopolysaccharides

@inproceedings{EDGARDOBiologicalAO,
  title={Biological Activities of Brucella abortus Lipopolysaccharides},
  author={EDGARDO and MORENO and T. DAVID and Berman and LOUISE A. BOETTCHER}
}
  • EDGARDO, MORENO, +2 authors LOUISE A. BOETTCHER
Purified lipopolysaccharide (LPS) from smooth (S) and rough (R) strains of Brucella abortus and lipid A isolated from S-LPS by mild acid hydrolysis were examined in several assays of biological activity. Brucella Sand R-LPSs and Brucella lipid A activated the complement cascade. Previously reported mitogenic activation by Brucella LPSs of spleen cells from endotoxin-resistant C3H/ HeJ mice was confirmed and also produced by isolated Brucella lipid A. Mitogenicity was not inhibited by polymyxin… CONTINUE READING