Biological, Geometric and Biomechanical Factors Influencing Abdominal Aortic Aneurysm Rupture Risk: A Comprehensive Review

  title={Biological, Geometric and Biomechanical Factors Influencing Abdominal Aortic Aneurysm Rupture Risk: A Comprehensive Review},
  author={Samarth S. Raut and Santanu Chandra and Judy Shum and Christopher B. Washington and Satish C. Muluk and Ender A. Finol and Jos{\'e} F{\'e}lix Rodr{\'i}guez},
  journal={Recent Patents on Medical Imaging},
The current clinical management of abdominal aortic aneurysm (AAA) disease is based to a great extent on measuring the aneurysm maximum diameter to decide when timely intervention is required. Decades of clinical evidence show that aneurysm diameter is positively associated with the probability of rupture, but that other parameters may also play a role in causing or predisposing the AAA to rupture. Biological factors associated with smooth muscle apoptosis are implicated in AAA expansion while… 
Correlation between Hemodynamic Stresses and Morphometric Indices as a Predictor Potential of Abdominal Aortic Aneurysm Rupture
Nowadays, there is consensus that current criteria to assess the abdominal aortic aneurysm rupture risk (maximum transverse diameter and growth rate) cannot be considered as reliable indicators.
Toward modeling the effects of regional material properties on the wall stress distribution of abdominal aortic aneurysms
A non-invasive patientspecific regional material property model is introduced to help understand and investigate the AAA wall stress distribution, peak wall stress (PWS) severity, and potential rupture risk and results show that to investigate AAA, the overall geometry, presence of intra-luminal thrombus (ILT), and loading condition in a patient specific manner may be critical for capturing the biomechanical complexity of AAAs.
A Comparative Study of Biomechanical and Geometrical Attributes of Abdominal Aortic Aneurysms in the Asian and Caucasian Populations.
It is revealed that geometric indices other than maximum AAA diameter can serve as predictors of wall stress, and potentially for assessment of aneurysm rupture risk, in the Asian and Caucasian AAA populations.
Statistical techniques for predicting rupture risk in abdominal aortic aneurysms: A contribution based on bootstrap
The present work explores the use of a specific statistical technique (the bootstrap technique) to predict, based on morphological correlations, the patient-specific aneurysm rupture risk, to provide greater understanding of this complex phenomenon.
On the Use of Geometric Modeling to Predict Aortic Aneurysm Rupture.
Role of intraluminal thrombus in abdominal aortic aneurysm ruptures: a hemodynamic point of view.
Hemodynamic characteristics influence the rupture mechanisms of particular AAAs differently on the basis of the presence and thickness of ILTs, which may increase the rupture risk of small AAAs because of their location in the sac lumen, which results in chaotic flow patterns and rapid increases in flow resistance.
Animal Model Dependent Response to Pentagalloyl Glucose in Murine Abdominal Aortic Injury
Two experimental murine models are used to evaluate the potential of pentagalloyl glucose (PGG), which is a polyphenolic tannin that binds to and crosslinks elastin and collagen, to preserve aortic compliance and suggest that PGG may reduce arterial calcium accumulation.
Targeted drug delivery of magnetic microbubble for abdominal aortic aneurysm: an in silico study
Targeted drug delivery (TDD) to abdominal aortic aneurysm (AAA) using a controlled and efficient approach has recently been a significant challenge. In this study, by using magnetic microbubbles
Biomechanical Restoration Potential of Pentagalloyl Glucose after Arterial Extracellular Matrix Degeneration
PGG binds to the hydrophobic core of arterial tissues and the crosslinking of ECM fibers is one of the possible explanations for the recovery of biomechanical properties observed in this study.


New approaches to abdominal aortic aneurysm rupture risk assessment: engineering insights with clinical gain.
There have been some significant steps, both numerically and experimentally, toward answering questions relating to AAA rupture risk prediction, yet regardless of the efforts that are under way in several laboratories, the introduction of a numerically predicted rupture risk parameter into the clinicians' decision-making process may still be quite some time away.
Quantitative Indicator of Abdominal Aortic Aneurysm Rupture Risk Based on its Geometric Parameters
A dimensionless rupture risk index, RI(t), which has been validated preliminarily with a clinical case and others from literature, and it is expected to be able to identify the one in aneurysm whose peak diameter is less than the threshold value.
Biomechanics of abdominal aortic aneurysm.
  • D. Vorp
  • Engineering, Biology
    Journal of biomechanics
  • 2007
Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling
Fuid–structure interaction simulations conducted in models reconstructed from CT scans of patients who had contained ruptured AAA predicted the rupture location based on mapping of the stresses developing within the aneurysmal wall, additionally showing that a smaller rAAA presented a higher rupture risk.
A review of biological factors implicated in abdominal aortic aneurysm rupture.
  • E. Choke, G. Cockerill, M. Thompson
  • Medicine
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
  • 2005
In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk.
Calculation of wall stress with computer modeling of three-dimensional AAA geometry appears to assess rupture risk more accurately than AAA diameter or other previously proposed clinical indices.
Abdominal aortic aneurysm risk of rupture: patient-specific FSI simulations using anisotropic model.
A new anisotropic material model of AAA that closely matches observed biomechanical AAA material properties was applied to FSI simulations of patient-specific AAA geometries in order to develop a more reliable predictor for its risk of rupture.
The influence of shape on the stresses in model abdominal aortic aneurysms.
It is hypothesized that the risk of rupture depends on AAA shape, and it is suggested that rupture probability should be based on wall curvatures, not on AAA bulge diameter.
Fluid-structure interaction in abdominal aortic aneurysms: effects of asymmetry and wall thickness
Both wall thickness and geometry asymmetry affect the stress exhibited by a virtual AAA, and the results suggest that an asymmetric AAA with regional variations in wall thickness would be exposed to higher mechanical stresses and an increased risk of rupture than a more fusiform AAA with uniform wall thickness.