Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids

  title={Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids},
  author={Tanya M. Teslovich and Kiran Musunuru and Albert Vernon Smith and Andrew C Edmondson and Ioannis M. Stylianou and Masahiro Koseki and James P. Pirruccello and Samuli Ripatti and Daniel Chasman and Cristen J. Willer and Christopher Johansen and Sigrid W. Fouchier and Aaron Isaacs and Gina Marie Peloso and Maja Barbali{\'c} and Sally L Ricketts and Joshua C Bis and Yurii S. Aulchenko and Gudmar Thorleifsson and Mary F Feitosa and John Campbell Chambers and Marju Orho-Melander and Olle Melander and Toby Johnson and Xiaohui Li and Xiuqing Guo and Mingyao Li and Yoon Shin Cho and Min Jin Go and Young Jin Kim and Jong-Young Lee and Taesung Park and Kyunga Kim and Xueling Sim and Rick Twee-Hee Ong and Damien C. Croteau-Chonka and Leslie A. Lange and Joshua D. Smith and Kijoung Song and Jing Hua Zhao and Xin Yuan and Jian'an Luan and Claudia Lamina and Andreas Ziegler and Weihua Zhang and Robert Y L Zee and Alan F. Wright and Jacqueline C. M. Witteman and James F Wilson and Gonneke A H M Willemsen and Heinz-Erich Wichmann and John B. Whitfield and Dawn Waterworth and Nicholas J Wareham and G{\'e}rard Waeber and Peter Vollenweider and Benjamin F. Voight and Veronique Vitart and Andr{\'e} G. Uitterlinden and Manuela Uda and Jaakko Tuomilehto and John R. Thompson and Toshiko Tanaka and Ida L Surakka and Heather M Stringham and Tim D. Spector and Nicole Soranzo and Johannes H Smit and Juha Sinisalo and Kaisa Silander and Eric J G Sijbrands and Angelo Scuteri and James M Scott and David Schlessinger and Serena Sanna and Veikko V Salomaa and Juha Saharinen and Chiara Sabatti and Aimo O Ruokonen and Igor Rudan and Lynda M. Rose and Robert Roberts and Mark J. Rieder and Bruce M. Psaty and Peter P. Pramstaller and Irene Pichler and Markus Perola and Brenda W J H Penninx and Nancy L Pedersen and Cristian Pattaro and Alex N. Parker and Guillaume Par{\'e} and Ben A. Oostra and Christopher J. O'Donnell and Markku S Nieminen and Deborah A. Nickerson and Grant W. Montgomery and Thomas Meitinger and Ruth Mcpherson and Mark I. McCarthy and Wendy L. Mcardle and David Masson and Nicholas G. Martin and Fabio Marroni and Massimo Mangino and Patrik K. E. Magnusson and Gavin Lucas and Robert N Luben and Ruth J. F. Loos and Maisa Lokki and Guillaume Lettre and Claudia Langenberg and Lenore J. Launer and Edward G. Lakatta and Reijo Laaksonen and Kirsten Ohm Kyvik and Florian Kronenberg and Inke R. K{\"o}nig and Kay-Tee Khaw and Jaakko Kaprio and Lee M. Kaplan and {\AA}sa Johansson and Marjo-Riitta Jarvelin and Anne-Sophie Janssens and Erik Ingelsson and Wilmar Igl and G. K. Hovingh and Jouke-Jan Hottenga and Albert Hofman and Andrew A Hicks and Christian Hengstenberg and Iris M. Heid and Caroline Hayward and Aki S. Havulinna and Nicholas D Hastie and Tamara B. Harris and Talin Haritunians and Alistair Scott Hall and Ulf Gyllensten and Candace Guiducci and Leif Groop and Elena T. Gonzalez and Christian Gieger and Nelson B. Freimer and Luigi Ferrucci and Jeanette Erdmann and Paul Elliott and Kenechi G. Ejebe and Angela D{\"o}ring and Anna F. Dominiczak and Serkalem Demissie and Panagiotis Deloukas and Eco J. C. de Geus and Ulf H de Faire and Gabriel J. Crawford and Francis S. Collins and Yii-Der I. Chen and Mark J. Caulfield and Harry Campbell and No{\"e}l P. Burtt and Lori L. Bonnycastle and Dorret I. Boomsma and S. Matthijs Boekholdt and Richard N Bergman and In{\^e}s Barroso and Stefania Bandinelli and Christie M. Ballantyne and Themistocles L. Assimes and Thomas Quertermous and David Altshuler and Mark Seielstad and Tien Yin Wong and E. Shyong Tai and Alan B. Feranil and Christopher W Kuzawa and Linda S. Adair and Herman A. Taylor and Ingrid B. Borecki and Stacey Bolk Gabriel and James G. Wilson and K{\'a}ri Stef{\'a}nsson and Unnur Thorsteinsdottir and Vilmundur Gudnason and Ronald M. Krauss and Karen L. Mohlke and Jos{\'e} M. Ordov{\'a}s and Patricia B. Munroe and Jaspal Singh Kooner and Alan Richard Tall and Robert A Hegele and John J. P. Kastelein and Eric E. Schadt and Jerome I. Rotter and Eric Boerwinkle and David P. Strachan and Vincent Mooser and Hilma H{\'o}lm and Muredach P. Reilly and Nilesh J. Samani and Heribert Schunkert and L. Adrienne Cupples and Manjinder S. Sandhu and Paul M. Ridker and Daniel J. Rader and Cornelia M van Duijn and Leena Peltonen and Gonçalo R. Abecasis and Michael Boehnke and Sekar Kathiresan},
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 × 10−8), with 59 showing genome-wide significant association with… CONTINUE READING
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