Biologic variation is important for interpretation of thyroid function tests.

@article{Andersen2003BiologicVI,
  title={Biologic variation is important for interpretation of thyroid function tests.},
  author={Stig Kjaer Andersen and Niels Henrik Bruun and Klaus Michael Pedersen and Peter Laurberg},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2003},
  volume={13 11},
  pages={
          1069-78
        }
}
Large variations exist in thyrotropin (TSH) and thyroid hormones in serum. The components of variation include preanalytical, analytical, and biologic variation. This is divided into between- and within-individual variation. The latter consists of circadian and seasonal differences although there are indicators of a genetically determined starting point. The ratio of within- to between-individual variation describes the reliability of population-based reference ranges. This ratio is low for… CONTINUE READING

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