Biologic targeting in the treatment of inflammatory bowel diseases

  title={Biologic targeting in the treatment of inflammatory bowel diseases},
  author={Matteo Bosani and Sandro Ardizzone and Gabriele Bianchi Porro},
  booktitle={Biologics : targets & therapy},
The etiology of inflammatory bowel disease (IBD) has not yet been clarified and immunosuppressive agents which nonspecifically reduce inflammation and immunity have been used in the conventional therapies for IBD. Evidence indicates that a dysregulation of mucosal immunity in the gut of IBD causes an overproduction of inflammatory cytokines and trafficking of effector leukocytes into the bowel, thus leading to an uncontrolled intestinal inflammation. Under normal situations, the intestinal… CONTINUE READING