Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame.

@article{Scaglioni1997BiologicPO,
  title={Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame.},
  author={Pier Paolo Scaglioni and Margherita Melegari and Jack R Wands},
  journal={Virology},
  year={1997},
  volume={233 2},
  pages={374-81}
}
It is now well recognized that mutations in the hepatitis B virus (HBV) genome occur during the natural course of chronic viral infection. Regions of the viral genome that are frequently affected by such mutations, rearrangements, and/or deletions generally involve the precore promoter, precore, and core as well as the preS gene regions. However, little is known regarding the biologic consequences of these mutations on the functional properties of the variant viral strains with respect to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Molecular Biology of the Hepatitis B Virus.’

  • A. McLachlan
  • ’ ’ CRC N . Engl . J . Med .
  • 1991
Highly Influential
4 Excerpts

Hepatitis B virus strains with mutations in the precore

  • 1995

Hepatitis of hepatitis B virus core mutants that inhibit viral replication

  • T. J. Laskus, Rakela, M. J. Nowicki, D. H. Persing
  • Virology
  • 1995

Hepatitis of hepatitis B virus core mutants that inhibit viral replication . Virology B virus core promoter sequence analysis in fulminant and chronic 205 , 112 – 120 . hepatitis

  • T. J. CharacterizationLaskus, M. J. Nowicki, D. H. Persing
  • Gastroenterology
  • 1995

Mayumi , with an epidemic of fulminant hepatitis

  • F. Tsuda, T. Tanaka, H. Okamoto, Y. Miyakawa
  • J . Virol .
  • 1995

Similar Papers

Loading similar papers…