Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. A comparison of eight contemporary grading systems.

@article{Leong2001BiologicMI,
  title={Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. A comparison of eight contemporary grading systems.},
  author={Anthony S.-Y. Leong and Raija T. Sormunen and Songkhun Vinyuvat and Raza Hamdani and C Suthipintawong},
  journal={American journal of clinical pathology},
  year={2001},
  volume={115 5},
  pages={709-18}
}
The relevance of 8 contemporary classification and grading systems for ductal carcinoma in situ (DCIS) of the breast was examined in 100 tumors by comparing DCIS grade with grade of the concurrent infiltrating ductal carcinoma (IDC). Besides tumor size and nodal status, the immunohistochemical parameters in both lesions were compared, including estrogen receptor, progesterone receptor, c-erbB-2 protein, E-cadherin, vimentin, Ki-67 (MIB1), and p27. Nuclear grading of DCIS alone or in combination… CONTINUE READING

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