Biologic effects of leukocytes present in transfused cellular blood products.

@article{Bordin1994BiologicEO,
  title={Biologic effects of leukocytes present in transfused cellular blood products.},
  author={Jos{\'e} Orlando Bordin and Nancy M. Heddle and Morris A. Blajchman},
  journal={Blood},
  year={1994},
  volume={84 6},
  pages={1703-21}
}
A considerable literature has accumulated over the past decade indicating that leukocytes present in allogeneic cellular blood components, intended for transfusion, are associated with adverse effects to the recipient. These include the development of febrile transfusion reactions, graft-versus-host disease, alloimmunization to leukocyte antigens, and the immunomodulatory effects that might influence the prognosis of patients with a malignancy. Moreover, it has become evident that such… CONTINUE READING

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