Biologic effects of leukocytes present in transfused cellular blood products.

  title={Biologic effects of leukocytes present in transfused cellular blood products.},
  author={Jos{\'e} Orlando Bordin and Nancy M. Heddle and Morris A. Blajchman},
  volume={84 6},
A considerable literature has accumulated over the past decade indicating that leukocytes present in allogeneic cellular blood components, intended for transfusion, are associated with adverse effects to the recipient. These include the development of febrile transfusion reactions, graft-versus-host disease, alloimmunization to leukocyte antigens, and the immunomodulatory effects that might influence the prognosis of patients with a malignancy. Moreover, it has become evident that such… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 77 extracted citations

Surgical Critical Care Therapy

Springer International Publishing • 2018
View 16 Excerpts
Highly Influenced

Anemia, blood loss, and blood transfusions in North American children in the intensive care unit.

American journal of respiratory and critical care medicine • 2008
View 6 Excerpts
Highly Influenced

Impact of Blood Transfusions on Survival of Locally Advanced Cervical Cancer Patients Undergoing Neoadjuvant Chemotherapy Plus Radical Surgery.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society • 2017


Publications referenced by this paper.
Showing 1-10 of 53 references

Compari - son of filtered blood ( FB ) to seronegative blood products ( SB ) for prevention of cytomegalovirus ( CMV ) infection after marrow transplant

RA Bowden, M Cays, +7 authors W Miller
Br J Haematol • 1993

Similar Papers

Loading similar papers…