• Corpus ID: 23243185

Biologic effects of implant debris.

  title={Biologic effects of implant debris.},
  author={Nadim James Hallab and Joshua J. Jacobs},
  journal={Bulletin of the NYU hospital for joint diseases},
  volume={67 2},
  • N. HallabJ. Jacobs
  • Published 2009
  • Biology, Materials Science
  • Bulletin of the NYU hospital for joint diseases
Biologic response to orthopedic implants debris is central to clinical performance. Eventual implant loosening due to aseptic osteolysis has been attributed to local inflammatory responses to wear and corrosion products that are produced by articulating implant interfaces. The response to implant debris is dominated by local immune activation, e.g. macrophages. Immune reactivity has been shown to depend on the number of particles produced or the dose (i.e., the concentration of phagocytosable… 

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