Biologic basis of osteoarthritis: state of the evidence.

  title={Biologic basis of osteoarthritis: state of the evidence.},
  author={Charles J. Malemud},
  journal={Current opinion in rheumatology},
  volume={27 3},
PURPOSE OF REVIEW Evidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather than a focal disorder of synovial joints. RECENT FINDINGS Inflammation was seen as the key component promoting synovitis as well as progression of cartilage and bone destruction in osteoarthritis. Thus, metabolic-triggered inflammation involving cytokines, adipokines, abnormal metabolites, acute phase reactants and even complement, all… CONTINUE READING
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