Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma.

@article{Gimotty2005BiologicAP,
  title={Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma.},
  author={Phyllis A. Gimotty and Patricia A Van Belle and David E. Elder and Todd C Murry and Kathleen T Montone and Xiaowei Xu and Susan E Hotz and Shane Raines and Michael E Ming and Peter Wahl and Dupont Guerry},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2005},
  volume={23 31},
  pages={8048-56}
}
PURPOSE Tumor cell proliferation is a central feature of melanoma progression. In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (< or = 1.00 mm) primary cutaneous melanomas and examined their association with prognosis. PATIENTS AND METHODS We used immunohistochemistry to determine Ki67 expression using the monoclonal antibody MIB-1 in lesions from a prospective cohort that included 396 patients with thin… CONTINUE READING

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