Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.

@article{Arendt2008BiologicAG,
  title={Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.},
  author={Bonnie K. Arendt and Marina Ram{\'i}rez-Alvarado and Laura A. Sikkink and Jonathan J. Keats and Gregory J. Ahmann and Angela Dispenzieri and Rafael Luı́s Fonseca and Rhett P. Ketterling and Ryan A. Knudson and Erin M Mulvihill and Renee C. Tschumper and Xiaosheng Wu and Steven R. Zeldenrust and Diane F. Jelinek},
  journal={Blood},
  year={2008},
  volume={112 5},
  pages={1931-41}
}
Primary systemic amyloidosis (AL) is a rare monoclonal plasma cell (PC) disorder characterized by the deposition of misfolded immunoglobulin (Ig) light chains (LC) in vital organs throughout the body. To our knowledge, no cell lines have ever been established from AL patients. Here we describe the establishment of the ALMC-1 and ALMC-2 cell lines from an AL patient. Both cell lines exhibit a PC phenotype and display cytokine-dependent growth. Using a comprehensive genetic approach, we… CONTINUE READING

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