Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer.

@article{Ware2014BiologicAC,
  title={Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer.},
  author={Kathryn E. Ware and Mariano A. Garcia-Blanco and Andrew James Armstrong and Scott M Dehm},
  journal={Endocrine-related cancer},
  year={2014},
  volume={21 4},
  pages={T87-T103}
}
As prostate cancer (PCa) progresses to the lethal castration resistant and metastatic form, genetic and epigenetic adaptation, clonal selection, and evolution of the tumor microenvironment contribute to the emergence of unique biological characteristics under the selective pressure of external stresses. These stresses include the therapies applied in the clinic or laboratory and the exposures of cancers to hormonal, paracrine, or autocrine stimuli in the context of the tumor micro- and macro… CONTINUE READING
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