Biologic Treatments for Sports Injuries II Think Tank—Current Concepts, Future Research, and Barriers to Advancement, Part 1

@article{LaPrade2016BiologicTF,
  title={Biologic Treatments for Sports Injuries II Think Tank—Current Concepts, Future Research, and Barriers to Advancement, Part 1},
  author={Robert F. LaPrade and Andrew G. Geeslin and Iain R. Murray and Volker Musahl and Jason P. Zlotnicki and Frank A. Petrigliano and Barton J. Mann},
  journal={The American Journal of Sports Medicine},
  year={2016},
  volume={44},
  pages={3270 - 3283}
}
Biologic therapies, including stem cells, platelet-rich plasma, growth factors, and other biologically active adjuncts, have recently received increased attention in the basic science and clinical literature. At the 2015 AOSSM Biologics II Think Tank held in Colorado Springs, Colorado, a group of orthopaedic surgeons, basic scientists, veterinarians, and other investigators gathered to review the state of the science for biologics and barriers to implementation of biologics for the treatment of… 
View on SAGE
drrobertlaprademd.com
90 Citations
Highly Influential Citations
2
Background Citations
19
Methods Citations
2

90 Citations

Citation Type

Citation Type

Biologic Treatments for Sports Injuries II Think Tank—Current Concepts, Future Research, and Barriers to Advancement, Part 2
TLDR
Current and emerging biologic approaches to augment rotator cuff tendon and muscle regeneration focusing on the scientific rationale, preclinical, and clinical evidence for efficacy, areas for future research, and current barriers to advancement and implementation are presented.
Biologics in Sports Medicine
TLDR
This chapter focuses on platelet-rich plasma and bone marrow concentrate especially their use in the outpatient setting and the research surrounding the use of biologic therapy.
Biologic Treatment of Ligament Injuries by the Sports Physician
TLDR
There is insufficient evidence to suggest that the use of biologics in ligament injuries provides any significant clinical benefit, but the results of preclinical and basic science studies are promising.
Biologic Association Annual Summit: 2020 Report
TLDR
The Biologic Association was created to foster coordinated efforts and speak with a unified voice, advocating for the responsible use of biologics in the musculoskeletal environment in clinical practice, spearheading the development of standards for treatment and outcomes assessment, and reporting on the safety and efficacy of biologic interventions.
Biological Treatment for Osteoarthritis of the Knee: Moving from Bench to Bedside-Current Practical Concepts.
  • J. Chahla, B. Mandelbaum
  • Medicine, Biology
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2018
A Practical Guide for the Current Use of Biologic Therapies in Sports Medicine
TLDR
Clinicians utilizing biologics must have a thorough understanding of the recently clarified Food and Drug Administration guidelines that regulate the clinical use of cell and tissue products and a lack of consensus on the optimal preparation, source, delivery method, and dosing of biologic therapies.
The Role of Orthobiologics in the Management of Tendon and Fascia Injuries in Sports
TLDR
This chapter will relay the most current evidence regarding the efficacy of different orthobiologics for the treatment of tendon injuries in athletes as well as recommend conservative measures, including rest, icing, physical therapy, and analgesics for symptomatic relief.
Level V Evidence Biological Treatment for Osteoarthritis of the Knee : Moving from Bench to Bedside d Current Practical Concepts
TLDR
This article aims to review the existing literature for biological-based treatment options for osteoarthritis, critically assessing the current evidence-based recommendations and identifying potential avenues for development.
Current perspectives on biological approaches for osteoarthritis
TLDR
There is a continued effort to produce a biological treatment modality tailored to target intra‐articular structures that recapitulates tissue function and will potentially optimize tissue healing, regeneration, and joint preservation strategies.
The use of biologics in professional and Olympic sport: a scoping review protocol
TLDR
This scoping review will aim to firstly map the current extent, range, and nature of evidence for biologic strategies to treat injuries in professional and Olympic sport, and to summarize and disseminate existing research findings, to identify gaps in existing literature.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 119 REFERENCES
How should we evaluate outcomes for use of biologics in the knee?
TLDR
Current strategies for evaluating outcomes after biologic treatment are reviewed and new recommendations for assessing outcomes following the use of biologics in the knee are proposed.
Application of Biologics in the Treatment of the Rotator Cuff, Meniscus, Cartilage, and Osteoarthritis
TLDR
Current preclinical animal and clinical human data and regulatory requirements are important to understand in light of public interest inTherapies are emerging that involve growth factors, blood‐derived products, marrow‐ derived products, and stem cells.
Novel approaches for the management of tendinopathy.
TLDR
Overall results suggest a trend for a positive effect of eccentric exercises, with no reported adverse effects, and combining eccentric training and shock wave therapy produces higher success rates compared with eccentric loading alone or shock wave Therapy alone.
Improving outcomes for posterolateral knee injuries
TLDR
The diagnosis and outcomes following treatment of posterolateral knee injuries have been significantly improved comparing the preoperative state to the state of the knee at a minimum 2 year follow-up in the cases series presented here.
Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries.
TLDR
Current findings in PRP basic science research, which have shed light on its proposed mechanisms of action, have opened doors for future areas of PrP research.
Stem Cell Applications in Tendon Disorders: A Clinical Perspective
  • M. Young
  • Medicine, Biology
    Stem cells international
  • 2012
TLDR
Even though cellular therapies offer some potential in treating tendon disorders, there have been few published clinical trials to determine the ideal cell source, the number of cells to administer, or the optimal bioscaffold for clinical use.
Tendon injury and tendinopathy: healing and repair.
TLDR
There is limited and mixed high-level evidence to support the, albeit common, clinical use of these modalities and further research and scientific evaluation are required before biological solutions become realistic options.
Sports medicine applications of platelet rich plasma.
TLDR
A classification for platelet rich plasma is proposed and the in-vitro, preclinical and human investigations of PRP applications in sports medicine will be reviewed as well as a discussion of rehabilitation after a PRP procedure.
Continuum model of tendon pathology – where are we now?
TLDR
The degree to which recent research supports or refutes the continuum model of tendon pathology is examined and future directions for clinical and research application of the model are proposed.
Use of a Bioactive Scaffold to Stimulate Anterior Cruciate Ligament Healing Also Minimizes Posttraumatic Osteoarthritis After Surgery
TLDR
Bioenhanced ACL repair produces a ligament that is biomechanically similar to an ACL graft and provides chondroprotection to the joint after ACL surgery and may provide a new, less invasive treatment option that reduces cartilage damage following joint injury.
...
1
2
3
4
5
...