Pathologic Basis of Disease,
- V. Kumar, S. Kotran R, L. Robbins S
- 6th ed.,
gram-negative infections. Unfortunately it causes renal failure in 10—20% of therapeutic courses. It has been demonstrated that GEN-induced nephrotoxicity is characterized by direct tubular necrosis, which is localized mainly in the proximal tubule. The exact mechanisms of GEN-induced nephrotoxicity still remain unclear. However GEN has been shown to enhance the generation of reactive oxygen species (ROS). ROS have been suggested as a causative agent of cell death in different pathological states including various models of renal diseases. Although a considerable number of studies have been devoted to the investigation of heart disease by antioxidants, the protective role of antioxidant in renal disease has been poorly analysed. However, the protective effects of some antioxidants such as manganese chloride and lycopene were investigated against lipid peroxidation induced by GEN and cisplatin. Furthermore, GEN induced nephrotoxicity was ameliorated by antioxidant vitamin E and garlic extracts. Resveratrol (RSV) is a natural polyphenol phytoalexin (trans-3,5,4 -trihydroxy stilbene) and possesses diverse biochemical and physiological actions, which includes estrogenic, antiplatelet and anti-inflammatory properties. In addition to these, resveratrol was found to exert its protective effect through upregulation of nitric oxide (NO) in kidney cells. Furthermore, it has a protective property against GEN induced lipid peroxidation and ameliorated glomerular filtration rate of renal blood flow and urinary excretion of Nacetyl-b-D-glucosaminidase. In the present study, we aimed to investigate the possible effect of resveratrol, as an antioxidant agent, during the GEN treatment, which could prevent the drug induced renal tubular necrosis, tubular vacuolization and parietal cell hyperplasia.