Bioinspired phosphorylcholine-modified polyplexes as an effective strategy for selective uptake and transfection of cancer cells.

@article{Chen2013BioinspiredPP,
  title={Bioinspired phosphorylcholine-modified polyplexes as an effective strategy for selective uptake and transfection of cancer cells.},
  author={Lina Chen and Hai-Bo Wang and Yuanfeng Zhang and Youxiang Wang and Qiaoling Hu and Jian Ji},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2013},
  volume={111},
  pages={297-305}
}
We demonstrated here that the phosphorylcholine-modified polyplexes can be explored as effective gene vector for selective uptake and high transfection of cancer cells. 12-acryloyloxy dodecyl phosphorylcholine modified polyethyleneimine (PEI-ADPC) with grafting level about 13%, 8.3% and 4.5% was successfully synthesized. Gel retardation assay indicated that ADPC modification did not affect the DNA condensation ability. The PEI-ADPC13%/DNA and PEI-ADPC8.3%/DNA polyplexes were under 100nm with a… CONTINUE READING

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