• Corpus ID: 92807854

Bioinorganic medicinal chemistry

  title={Bioinorganic medicinal chemistry},
  author={Enzo Alessio},
MEDICINAL INORGANIC CHEMISTRY: STATE OF THE ART, NEW TRENDS, AND A VISION OF THE FUTURE Introduction Antimicrobial Agents Antiviral Agents Systemic and Metabolic Diseases Including Inflammation Metal Chelating Agents Antiarthritic Drugs and Inflammation Bipolar Disorder Anticancer Agents Small Molecule Delivery and Control Diagnostic Agents Veterinary Medicinal Inorganic Chemistry Conclusions and Vision TARGETING STRATEGIES FOR METAL-BASED THERAPEUTICS Introduction Physiological Targeting… 
Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives.
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Monofunctional and higher-valent platinum anticancer agents.
Recent developments from the laboratory involving monofunctional platinum(II) complexes are described together with a historical account of the manner by which they came to investigate these compounds and their relationship to previously studied molecules.
Phosphine- and Isatin-Copper Complexes: Anticancer Activity, Mechanisms of Action and Structure-Activity Relationship Examples from the Last Ten Years
Platinum-based metallodrugs candidates are extensively evaluated as antineoplastic agents against several tumoral cell lines, representing a considerable advance in cancer treatment. On the other
Towards the Synthesis of New Tumor Targeting Photosensitizers for Photodynamic Therapy and Imaging Applications
Targeting peptides are very promising molecules to increase tumor selectivity of anticancer drugs. Herein, we report the synthesis of three complexes, which might act at the same time as
Structurally characterized copper-chrysin complexes display genotoxic and cytotoxic activity in human cells
Abstract The scientific interest in the development of novel anticancer metallodrugs with improved clinical efficiency and pharmacological properties based on a variety of metal ions and naturally
Role of nanostructure molecules in enhancing the bioavailability of oral drugs
Almost all living systems usually based on unique complex nanostructure to control the bimolecular interactions and biochemical reactions that play an important role in metabolism and reproduction.
Classification of Metal-based Drugs According to Their Mechanisms of Action.
A better understanding of the roles played by metal compounds at a mechanistic level will help to deliver new metal-based therapies to the clinic, by providing an alternative, targeted and rational approach, to supplement non-targeted screening of novel chemical entities for biological activity.
The potential of organometallic complexes in medicinal chemistry.
This short review presents the specific advantages that organometallic metal complexes have over purely organic and also coordination compounds and illustrates how these particular properties can be put to good use in medicinal chemistry.
Review of comparative studies of cytotoxic activities of Pt(II), Pd(II), Ru(II)/(III) and Au(III) complexes, their kinetics of ligand substitution reactions and DNA/BSA interactions
Abstract New concepts and various strategies are being explored to improve the cytotoxicity of metal-based complexes. One of those strategies is to fine-tune the substitution kinetics of
The Ferrocifen Family as Potent and Selective Antitumor Compounds: Mechanisms of Action
Chemical Biology, a discipline that links chemical engineering and biology, differs from biochemistry by positioning itself as a broad chemical domain that makes available to biology the tools and