Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.


The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This… (More)
DOI: 10.1021/acs.biochem.7b01305


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