Bioinformatics and molecular modelling approaches to GPCR oligomerization.

@article{Simpson2010BioinformaticsAM,
  title={Bioinformatics and molecular modelling approaches to GPCR oligomerization.},
  author={Lisa M Simpson and Bruck Taddese and Ian D Wall and Christopher A. Reynolds},
  journal={Current opinion in pharmacology},
  year={2010},
  volume={10 1},
  pages={30-7}
}
The elusive nature of the structure and function of the G-protein coupled receptor (GPCR) dimer or oligomer has led to a variety of computational studies, most of which have been directed primarily towards understanding structure. Here we review some of the recent studies based on sequence analysis and docking experiments and the recent developments in GPCR structure that have underpinned dimerization studies. In addition, we review recent nanosecond molecular dynamics simulations and coarse… CONTINUE READING