Bioinformatics and mathematical modelling in the study of receptor-receptor interactions and receptor oligomerization: focus on adenosine receptors.

@article{Guidolin2011BioinformaticsAM,
  title={Bioinformatics and mathematical modelling in the study of receptor-receptor interactions and receptor oligomerization: focus on adenosine receptors.},
  author={Diego Guidolin and Francisco Ciruela and Susanna Genedani and Michele Guescini and Cinzia Tortorella and G. Albertin and Kjell Fuxe and Luigi Francesco Agnati},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1808 5},
  pages={1267-83}
}
The concept of intra-membrane receptor-receptor interactions (RRIs) between different types of G protein-coupled receptors (GPCRs) and evidence for their existence was introduced by Agnati and Fuxe in 1980/81 through the biochemical analysis of the effects of neuropeptides on the binding characteristics of monoamine receptors in membrane preparations from discrete brain regions and functional studies of the interactions between neuropeptides and monoamines in the control of specific functions… CONTINUE READING

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